Christine Guthrie, PhD
Professor christineguthrie@gmail.com
Dr. Christine Guthrie, a Professor in the Department of Biochemistry and Biophysics at the University of California, San Francisco, is a leader in the field of RNA biology and genetics. She helped found the field of splicing and its regulation and helped pioneer the innovative application of single molecule FRET to studies of spliceosome dynamics. The Guthrie laboratory focuses on two major steps in gene expression, mRNA splicing and export, with the long-term goal to understand at a molecular level the mechanisms responsible for specificity and fidelity in these pathways. The lab's work of the last 25 years has been instrumental in establishing that the spliceosome is a highly dynamic RNA-protein machine that relies on RNA-dependent ATPases of the so-called DEAD-box family to promote multiple conformational rearrangements during assembly, catalysis and disassembly. Present work focuses on determining how these conformational rearrangements promote splicing fidelity. Dr. Guthrie is a member of the National Academy of Sciences and an American Cancer Society Research Professor of Molecular Genetics.
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